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Associate Professor
Department of Functional Neurology & Neurosurgery


2011.04— Associate Professor of Department of Functional Neurology & Neurosurgery
2005.09—2011.03 Assistant Professor of Center for Transdisciplinary Research
2005.04—2005.08 Resercher of Graduate School of Medical Science, Niigata University
2004.04—2005.03 Resercher of Graduate School of Medical Science, Kanazawa University
2003.06—2004.03 Resercher of Mitsubishi Kagaku Institute of Life Sciences
2003.04—2003.05 Resercher of Graduate School of Medical Science, Niigata University
2001.04—2003.03 Reserch Fellow of The Japan Society for the Promotion of Science
2000.04—2001.03 Post Doctal Fellow of The Japan science and Technology Corporation
2000.03 Ph.D., Medical Sciences, University of Tokyo
1996.03 M.Eng. Fukui University


  1. Ikeda T, Takahashi T, Tsujita M, Kanazawa M, Toriyabe M, Koyama M, Itoh K, Nakada T, Nishizawa M, Shimohata T. Effects of Alda-1, an Aldehyde Dehydrogenase-2 Agonist, on Hypoglycemic Neuronal Death. PLoS One. 2015 ;10(6):e0128844.
  2. Otsu Y, Marcaggi P, Feltz A, Isope P, Kollo M, Nusser Z, Mathieu B, Kano M, Tsujita M, Sakimura K, Dieudonné S. Activity-Dependent Gating of Calcium Spikes by A-type K+ Channels Controls Climbing Fiber Signaling in Purkinje Cell Dendrites. Neuron. 2014; 84(1):137-51
  3. Igarashi H, Tsujita M, Kwee IL, Nakada T. Water influx into cerebrospinal fluid is primarily controlled by aquaporin-4, not by aquaporin-1: 17O JJVCPE MRI study in knockout mice. Neuroreport. 2014; 25(1):39-43.
  4. Igarashi H, Tsujita M, Suzuki Y, Kwee IL, Nakada T. Inhibition of aquaporin-4 significantly increases regional cerebral blood flow. Neuroreport. 2013;24(6):324-8.
  5. Suzuki Y, Nakamura Y, Yamada K, Huber VJ, Tsujita M, Nakada T. Aquaporin-4 positron emission tomography imaging of the human brain: first report. J. Neuroimaging. 2013; 23(2): 219-23.
  6. Huber VJ, Tsujita M, Nakada T. Aquaporins in drug discovery and pharmacotherapy. Mol Aspects Med. 2012; 33(5-6): 691-703.
  7. Nakamura Y, Suzuki Y, Tsujita M, Huber VJ, Yamada K, Nakada T. Development of a Novel Ligand, [C]TGN-020, for Aquaporin 4 Positron Emission Tomography Imaging.ACS Chem Neurosci. 2011;2(10):568-571.
  8. Hashimoto K, Tsujita M, Miyazaki T, Kitamura K, Yamazaki M, Shin HS, Watanabe M, Sakimura K, Kano M. Postsynaptic P/Q-type Ca2+ channel in Purkinje cell mediates synaptic competition and elimination in developing cerebellum. Proc Natl Acad Sci U S A. 2011; 108(24):9987-92.
  9. Igarashi H, Huber VJ, Tsujita M, Nakada T. Pretreatment with a novel aquaporin 4 inhibitor, TGN-020, significantly reduces ischemic cerebral edema. Neurol Sci. 2010; 32 :113-116.
  10. Watanabe Y, Takeuchi K, Higa Onaga S, Sato M, Tsujita M, Abe M, Natsume R, Li M, Furuichi T, Saeki M, Izumikawa T, Hasegawa A, Yokoyama M, Ikegawa S, Sakimura K, Amizuka N, Kitagawa H, Igarashi M. Chondroitin sulfate N-acetylgalactosaminyltransferase-1 is required for normal cartilage development. Biochem J. 2010; 432 (1) :47-55.
  11. Yamazaki M, Fukaya M, Hashimoto K, Yamasaki M, Tsujita M, Itakura M, Abe M, Natsume R, Takahashi M, Kano M, Sakimura K, Watanabe M. TARPs gamma-2 and gamma-7 are essential for AMPA receptor expression in the cerebellum. Eur J Neurosci. 2010; 31 (12) :2204-20.
  12. Yanagawa K, Kawachi I, Toyoshima Y, Yokoseki A, Arakawa M, Hasegawa A, Ito T, Kojima N, Koike R, Tanaka K, Kosaka T, Tan CF, Kakita A, Okamoto K, Tsujita M, Sakimura K, Takahashi H, Nishizawa M. Pathologic and immunologic profiles of a limited form of neuromyelitis optica with myelitis. Neurology. 2009; 73 (20) :1628-37.
  13. Tani T, Sakimura K, Tsujita M, Nakada T, Tanaka M, Nishizawa M, Tanaka K. Identification of binding sites for anti-aquaporin 4 antibodies in patients with neuromyelitis optica. J Neuroimmunol. 2009; 211 (1-2) :110-3.
  14. Kitaura H, Tsujita M, Huber VJ, Kakita A, Shibuki K, Sakimura K, Kwee IL, Nakada T. Activity-dependent glial swelling is impaired in aquaporin-4 knockout mice. Neurosci Res. 2009; 64 (2) :208-12.
  15. Huber VJ, Tsujita M, Nakada T. Identification of aquaporin 4 inhibitors using in vitro and in silico methods. Bioorg Med Chem. 2009; 17 (1) :411-7.
  16. Huber VJ, Tsujita M, Kwee IL, Nakada T. Inhibition of aquaporin 4 by antiepileptic drugs. Bioorg Med Chem. 2009; 17 (1) :418-24.
  17. Tanaka K, Tani T, Tanaka M, Saida T, Idezuka J, Yamazaki M, Tsujita M, Nakada T, Sakimura K, Nishizawa M. Anti-aquaporin 4 antibody in selected Japanese multiple sclerosis patients with long spinal cord lesions. Mult Scler. 2007; 13 (7) :850-5.
  18. Petrenko AB, Tsujita M, Kohno T, Sakimura K, Baba H. Mutation of alpha1G T-type calcium channels in mice does not change anesthetic requirements for loss of the righting reflex and minimum alveolar concentration but delays the onset of anesthetic induction. Anesthesiology. 2007; 106 (6) :1177-85.
  19. Huber VJ, Tsujita M, Yamazaki M, Sakimura K, Nakada T. Identification of arylsulfonamides as Aquaporin 4 inhibitors. Bioorg Med Chem Lett. 2007; 17 (5) :1270-3.
  20.  Fukaya M, Tsujita M, Yamazaki M, Kushiya E, Abe M, Akashi K, Natsume R, Kano M, Kamiya H, Watanabe M, Sakimura K. Abundant distribution of TARP gamma-8 in synaptic and extrasynaptic surface of hippocampal neurons and its major role in AMPA receptor expression on spines and dendrites. Eur J Neurosci. 2006; 24 (8) :2177-90.
  21. Takeuchi T, Nomura T, Tsujita M, Suzuki M, Fuse T, Mori H, Mishina M. Flp recombinase transgenic mice of C57BL/6 strain for conditional gene targeting. Biochem Biophys Res Commun. 2002; 293 (3) :953-7.
  22. Ohsawa N, Tsujita M, Morikawa S, Itoh N. Purification and characterization of a monohalomethane-producing enzyme S-adenosyl-L-methionine: halide ion methyltransferase from a marine microalga, Pavlova pinguis. Biosci Biotechnol Biochem. 2001; 65 (11) :2397-404.
  23. Takeuchi T, Kiyama Y, Nakamura K, Tsujita M, Matsuda I, Mori H, Munemoto Y, Kuriyama H, Natsume R, Sakimura K, Mishina M. Roles of the glutamate receptor epsilon2 and delta2 subunits in the potentiation and prepulse inhibition of the acoustic startle reflex. Eur J Neurosci. 2001; 14 (1) :153-60.
  24. Tsujita M, Mori H, Watanabe M, Suzuki M, Miyazaki J, Mishina M. Cerebellar granule cell-specific and inducible expression of Cre recombinase in the mouse. J Neurosci. 1999; 19 (23) :10318-23.
  25. Itoh, N, Tsujita, M, Ando, T, Hisatomi, G, Higashi, T. Formation and emission of monohalomethanes from marine algae. Phytochemistry 1997; 45 :67-73.

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